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Noriko Uchiyama Selected Research

Schizophrenia (Dementia Praecox)

1/2017Discovery of Clinical Candidate N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders.

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Noriko Uchiyama Research Topics

Disease

8Neoplasms (Cancer)
08/2020 - 03/2012
4Alzheimer Disease (Alzheimer's Disease)
01/2017 - 03/2009
2Neurodegenerative Diseases (Neurodegenerative Disease)
01/2021 - 01/2017
2Cognitive Dysfunction
01/2017 - 01/2017
1Prostatic Neoplasms (Prostate Cancer)
10/2017
1Phototoxic Dermatitis (Phototoxicity)
01/2017
1Schizophrenia (Dementia Praecox)
01/2017
1Colorectal Neoplasms (Colorectal Cancer)
03/2012
1Leukemia
03/2012
1Amyloid Plaque
12/2011
1Tauopathies
11/2009
1Disease Progression
11/2009
1Neuralgia (Stump Neuralgia)
09/2008
1Bone Resorption
09/2008

Drug/Important Bio-Agent (IBA)

2hypusineIBA
08/2020 - 01/2020
2EnzymesIBA
08/2020 - 01/2017
2Histones (Histone)IBA
10/2017 - 01/2017
2Phosphoric Diester Hydrolases (Phosphodiesterases)IBA
01/2017 - 01/2017
2Cyclic NucleotidesIBA
01/2017 - 01/2017
2PyrazinesIBA
01/2017 - 01/2017
2Type 2 Cyclic Nucleotide PhosphodiesterasesIBA
01/2017 - 01/2017
24- ((9- cyclopentyl- 7,7- difluoro- 5- methyl- 6- oxo- 6,7,8,9- tetrahydro- 5H- pyrimido(4,5- b)(1,4)diazepin- 2- yl)amino)- 2- fluoro- 5- methoxy- N- (1- methylpiperidin- 4- yl)benzamideIBA
06/2013 - 03/2012
2Glycogen Synthase Kinase 3IBA
12/2011 - 11/2009
2Glycogen Synthase (Synthase I)IBA
12/2011 - 03/2009
1hexosaminidase CIBA
01/2021
1deoxyhypusine synthaseIBA
08/2020
1Eukaryotic Translation Initiation Factor 5AIBA
08/2020
1Oncogene Proteins (Oncogene Protein)IBA
01/2020
1Messenger RNA (mRNA)IBA
01/2020
1DNA (Deoxyribonucleic Acid)IBA
01/2018
1Indicators and Reagents (Reagents)IBA
01/2018
1MicroRNAs (MicroRNA)IBA
10/2017
1aristeromycinIBA
10/2017
13-deazaneplanocinIBA
10/2017
1AndrogensIBA
10/2017
1HomocysteineIBA
10/2017
1Hormones (Hormone)IBA
10/2017
1pyrimidineIBA
01/2017
1Pharmaceutical PreparationsIBA
01/2017
1Paclitaxel (Taxol)FDA LinkGeneric
03/2012
1Doxorubicin (Adriamycin)FDA LinkGeneric
03/2012
1OxadiazolesIBA
12/2011
1Amyloid (Amyloid Fibrils)IBA
12/2011
1benzofuranIBA
12/2011
1Glycogen Synthase KinasesIBA
10/2009
1tau Proteins (tau Protein)IBA
03/2009
1cathepsin SIBA
09/2008
1Cathepsin KIBA
09/2008

Therapy/Procedure

5Therapeutics
01/2018 - 03/2012
2Oral Administration
03/2012 - 09/2008